منابع مشابه
Malarial Pigment (hematin) as a Factor in the Production of the Malarial Paroxysm
The paroxysm of hematin intoxication in the rabbit undoubtedly presents many features of striking similarity to the paroxysm of human malaria; still one must hesitate to apply such results unreservedly in an attempt to identify the causative agent of the malarial paroxysm. When, in addition to the character of the paroxysm, we consider the sequence of events in the two instances, the analogy be...
متن کاملHemozoin (Malarial Pigment) Directly Promotes Apoptosis of Erythroid Precursors
Severe malarial anemia is the most common syndrome of severe malaria in endemic areas. The pathophysiology of chronic malaria is characterised by a striking degree of abnormal development of erythroid precursors (dyserythropoiesis) and an inadequate erythropoietic response in spite of elevated levels of erythropoietin. The cause of dyserythropoiesis is unclear although it has been suggested tha...
متن کاملHemozoin Pigment: An Important Tool for Low Parasitemic Malarial Diagnosis
Low parasitemic condition in malaria remains a diagnostic challenge; as the available diagnostic methods failed to detect. Currently, hemozoin (Hz) pigment is gaining attention in the diagnosis of malaria. The major drawback is ease of detection of Hz in routine practice. A pilot study was conducted to evaluate the role of Hz pigment and to compare the performance of quantitative buffy coat ass...
متن کاملMalarial Pigment Hemozoin and the Innate Inflammatory Response
Malaria is a deadly infectious disease caused by the intraerythrocytic protozoan parasite Plasmodium. The four species of Plasmodium known to affect humans all produce an inorganic crystal called hemozoin (HZ) during the heme detoxification process. HZ is released from the food vacuole into circulation during erythrocyte lysis, while the released parasites further infect additional naive red bl...
متن کاملMalarial Pigment (hematin) as an Active Factor in the Production of the Blood Picture of Malaria
1. Intravenous injections of alkaline hematin in the rabbit produce an anemia the severity of which is proportional to the amount of hematin injected and the susceptibility of the animal. 2. Hemoglobinemia is an occasional consequence of hematin poisoning. 3. The leucocytes in hematin intoxication are usually increased in number and are always characterized by a high percentage of large mononuc...
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ژورنال
عنوان ژورنال: BMJ
سال: 1969
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5657.635-b